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Article

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia

16 Oct 2002

Abstract excerpt

Activating length mutations in the juxtamembrane (JM) domain of the FLT3 gene (FLT3-LM) and mutations in the catalytic domain (FLT3D835/836) of this receptor tyrosine kinase represent the most frequent genetic alterations in acute myeloid leukemia (AML). Here, we describe a 6-bp insertion in the activation loop of FLT3 between codons 840 and 841 of FLT3 (FLT3-840GS) in 2 unrelated patients with AML. Screening for...

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Identifiers

PMID: 12384447
DOI: 10.1182/blood-2002-03-0953

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