Article
The DNA-binding domain of the Escherichia coli CpxR two-component response regulator is constitutively active and cannot be fully attenuated by fused adjacent heterologous regulatory domains.
Microbiology (Reading, England) - 1 Feb 2006
Tapparel Caroline, Monod Antoinette, Kelley William L
Abstract excerpt
Two-component systems (TCS) based on a sensor histidine kinase and a phosphorylated cognate target regulator allow rapid responses to environmental changes. TCS are highly evolutionarily conserved, though in only a few cases are the inducing signals understood. This study focuses on the Escherichia coli CpxR response regulator that responds to periplasmic and outer-membrane stress. N-terminal deletion mutations...
Topics
- Bacterial Proteins
- DNA-Binding Proteins
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Genes, Regulator
- Mutation
- Protein Kinases
- Protein Structure, Tertiary