Article
Reduced expression of the TSP1 gene and its association with promoter hypermethylation in gastric carcinoma.
Oncology - 1 Jan 2003
Oue Naohide, Matsumura Shunji, Nakayama Hirofumi, Kitadai Yasuhiko, Taniyama Kiyomi, Matsusaki Keisuke, Yasui Wataru
Abstract excerpt
Thrombospondin-1 (TSP1) is a potent peptide shown in some tumor systems to be linked with angiogenesis. Epigenetic alteration of TSP1 has been reported in various primary tumors. However, the expression pattern of TSP1 has not been characterized in gastric carcinoma. We measured levels of TSP1 mRNA expression using quantitative RT-PCR in 30 gastric carcinomas and 10 non-neoplastic mucosae. In addition, we...
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