Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation induction with UVB in mouse skin epidermis is suppressed in acute high-dose exposure.

Mutation research - 31 Oct 2002

Ikehata Hironobu, Ono Tetsuya

Abstract excerpt

The time and dose dependence of ultraviolet B (UVB)-induced mutant frequency (MF) in skin epidermis and dermis was studied with transgenic Muta mice harboring lambdagt10lacZ shuttle vector. Mutants of the lacZ transgene appearing in these tissues after 0.5kJ/m(2) UVB irradiation were fully expressed in 3-7 days, and the frequencies of those fully expressed mutants were maintained for at least the following 3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Dermis
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epidermis

Share to Mice, Transgenic

Share to Time Factors

Share to Ultraviolet Rays

Source

Identifiers

PMID: 12379460
DOI: 10.1016/s0027-5107(02)00145-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation induction with UVB in mouse skin epidermis is suppressed in acute high-dose exposure.PMID 12379460Read ↗

Mutation spectrum in sunlight-exposed mouse skin epidermis: small but appreciable contribution of oxidative stress-mediated mutagenesis.Semantic proximity Read ↗

UVA induces C-->T transitions at methyl-CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB.Semantic proximity Read ↗

Analysis of mutation spectra in UVB-exposed mouse skin epidermis and dermis: frequent occurrence of C-->T transition at methylated CpG-associated dipyrimidine sites.Semantic proximity Read ↗

Action spectrum analysis of UVR genotoxicity for skin: the border wavelengths between UVA and UVB can bring serious mutation loads to skin.Semantic proximity Read ↗

UVB-induced gpt mutations in the skin of gpt delta transgenic mice.Semantic proximity Read ↗

Skin can control solar UVR-induced mutations through the epidermis-specific response of mutation induction suppression.Semantic proximity Read ↗

In Vivo Spectrum of UVC-induced Mutation in Mouse Skin Epidermis May Reflect the Cytosine Deamination Propensity of Cyclobutane Pyrimidine Dimers.Semantic proximity Read ↗

X-ray- and ultraviolet-radiation-induced mutations in Muta mouse.Semantic proximity Read ↗

UVB-induced mutagenesis in hairless lambda lacZ-transgenic mice.Semantic proximity Read ↗

UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin.Semantic proximity Read ↗

Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy.Semantic proximity Read ↗

Simulated solar light-induced p53 mutagenesis in SKH-1 mouse skin: a dose-response assessment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.