Article
The genomic structure and promoter region of the human parkin gene.
Biochemical and biophysical research communications - 7 Sept 2001
Asakawa S, Tsunematsu Ki, Takayanagi A, Sasaki T, Shimizu A, Shintani A, Kawasaki K, Mungall A J, Beck S, Minoshima S, Shimizu N
Abstract excerpt
Parkin has been identified as a causative gene of the autosomal recessive juvenile parkinsonism (AR-JP). In this study, we determined the genomic structure of the Parkin gene and identified a core promoter region based on the DNA sequence of 1.4 Mb. The 5'-flanking region contained no apparent TATA or CAAT box elements but several putative cis-elements for various transcription factors. The GC- and CpG-rich...
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