Article
Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.
Molecular and cellular biology - 1 Nov 2002
Ohlrogge Wiebke, Haag Friedrich, Löhler Jürgen, Seman Michel, Littman Dan R, Killeen Nigel, Koch-Nolte Friedrich
Abstract excerpt
This is the first study reporting the inactivation of a member of the mouse gene family of toxin-related ecto-ADP-ribosyltransferases (ARTs). Transfer of the ADP-ribose moiety from NAD onto extracellular arginine residues on T-cell membrane proteins is mediated by glycosylphosphatidylinositol-linked cell surface ARTs. Exposure of T cells to ecto-NAD blocks T-cell activation and induces T-cell apoptosis. To...
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