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Article

Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element.

Molecular and cellular biology - 1 Nov 2002

Kuwata Takeshi, Gongora Celine, Kanno Yuka, Sakaguchi Kazuyasu, Tamura Tomohiko, Kanno Tomohiko, Basrur Venkatesha, Martinez Robert, Appella Ettore, Golub Todd, Ozato Keiko

Abstract excerpt

ICSBP (IRF-8) is a transcription factor of the IRF family expressed only in the immune system. It is induced in macrophages by gamma interferon (IFN-gamma) and contributes to macrophage functions. By interacting with Ets family protein PU.1, ICSBP binds to the IRF/Ets composite element and stimulates transcription. ICSBP binds to another DNA element, the IFN-stimulated response element (ISRE), a common target of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12370291
DOI: 10.1128/MCB.22.21.7439-7448.2002
PMCID: PMC135656

Genes

HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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