Article
Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity.
Journal of lipid research - 1 May 2002
Tomás Marta, Elosua Roberto, Sentí Mariano, Molina Luis, Vila Joan, Anglada Roger, Fitó Montserrat, Covas Maria Isabel, Marrugat Jaume
Abstract excerpt
Regular exercise practise is a protective factor against coronary heart disease and enhances antioxidant systems, whereas acute exercise appears to be a major source of increased oxidative stress. Paraoxonase1 (PON1) is an antioxidant HDL-linked enzyme, whose activity toward paraoxon (PON1 activity) is strongly modulated by the PON1-192 polymorphism, comprising Q and R alleles for low and high PON1 activity,...
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