Article
Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth.
The Journal of clinical endocrinology and metabolism - 1 Oct 2002
Martelli Maria Luisa, Iuliano Rodolfo, Le Pera Ilaria, Sama' Irene, Monaco Carmen, Cammarota Simona, Kroll Todd, Chiariotti Lorenzo, Santoro Massimo, Fusco Alfredo
Abstract excerpt
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor involved in such cellular processes as adipogenesis, inflammation, atherosclerosis, cell cycle control, apoptosis, and carcinogenesis. PPAR gamma gene mutations have been found in 4 of 55 sporadic colon cancers, and a chimeric PAX8-PPAR gamma 1 gene frequently generates a chromosomal translocation in thyroid follicular carcinomas,...
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