Article
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2000
Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman D S, Oh W, Demetri G, Figg W D, Zhou X P, Eng C, Spiegelman B M, Kantoff P W
Abstract excerpt
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear hormone receptor that plays a key role in the differentiation of adipocytes. Activation of this receptor in liposarcomas and breast and colon cancer cells also induces cell growth inhibition and differentiation. In the present study, we show that PPARgamma is expressed in human prostate adenocarcinomas and cell lines derived from these...
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