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Article

Regulation of TSC2 by 14-3-3 binding.

The Journal of biological chemistry - 22 Nov 2002

Li Yong, Inoki Ken, Yeung Raymond, Guan Kun-Liang

Abstract excerpt

Mutation in either the TSC1 or TSC2 tumor suppressor gene is responsible for the inherited genetic disease of tuberous sclerosis complex. TSC1 and TSC2 form a physical and functional complex to regulate cell growth. Recently, it has been demonstrated that TSC1.TSC2 functions to inhibit ribosomal S6 kinase and negatively regulate cell size. TSC2 is negatively regulated by Akt phosphorylation. Here, we report that...

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Share to 14-3-3 Proteins
Share to Proto-Oncogene Proteins c-akt
Share to Ribosomal Protein S6 Kinases, 90-kDa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12364343
DOI: 10.1074/jbc.C200510200

Genes

TSC2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of TSC2 by 14-3-3 binding.PMID 12364343Read ↗

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