Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TSC complex decrease the expression of mTOR by regulated miR-199b-3p

13 Jan 2025

Abstract excerpt

The TSC complex formed by TSC1 and TSC2 is the most important upstream negative regulator of mTORC1. Genetic variations in either TSC1 or TSC2 cause tuberous sclerosis complex (TSC) disease which is a rare autosomal dominant disorder resulting in impairment of multiple organ systems. In this study, besides a reported variation, c.2509_2512del (p.Asn837Valfs*11, p.N837fs) in TSC1, we found a de novo TSC2 variation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mast cells and histamine
Share to PI3K/AKT/mTOR signaling in cancer
Share to Tuberous Sclerosis Complex Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39806027
DOI: 10.1038/s41598-025-85706-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TSC complex decrease the expression of mTOR by regulated miR-199b-3pPMID 39806027Read ↗

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatmentSemantic proximity Read ↗

The dual role of the TSC complex in cancer.Semantic proximity Read ↗

Tuberous sclerosis complex: From molecular biology to novel therapeutic approaches.Semantic proximity Read ↗

Tuberous Sclerosis ComplexSemantic proximity Read ↗

Dysregulation of the TSC-mTOR pathway in human diseaseSemantic proximity Read ↗

Perfect match: mTOR inhibitors and tuberous sclerosis complexSemantic proximity Read ↗

A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway.Semantic proximity Read ↗

Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis ComplexSemantic proximity Read ↗

Therapeutic Approaches to Tuberous Sclerosis Complex: From Available Therapies to Promising Drug TargetsSemantic proximity Read ↗

Tuberous sclerosis complex.Semantic proximity Read ↗

mTOR inhibitors in the pharmacologic management of tuberous sclerosis complex and their potential role in other rare neurodevelopmental disordersSemantic proximity Read ↗

TSC1/TSC2 signaling in the CNSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.