Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Class 3 semaphorins negatively regulate dermal lymphatic network formation

28 Aug 2015

Abstract excerpt

The development of a patterned lymphatic vascular network is essential for proper lymphatic functions during organ development and homeostasis. Here we report that class 3 semaphorins (SEMA3s), SEMA3F and SEMA3G negatively regulate lymphatic endothelial cell (LEC) growth and sprouting to control dermal lymphatic network formation. Neuropilin2 (NRP2) functions as a receptor for SEMA3F and SEMA3G, as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Axon Guidance and Neuronal Signaling
Share to Lymphatic System and Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26319580
DOI: 10.1242/bio.012302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Class 3 semaphorins negatively regulate dermal lymphatic network formationPMID 26319580Read ↗

Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1Semantic proximity Read ↗

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.Semantic proximity Read ↗

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3Semantic proximity Read ↗

Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.Semantic proximity Read ↗

Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.Semantic proximity Read ↗

Neuropilins: structure, function and role in diseaseSemantic proximity Read ↗

Review of the function of SEMA3A in lymphatic vessel maturation and its potential as a candidate gene for lymphedema: Analysis of three families with rare causative variants.Semantic proximity Read ↗

Abnormal lymphatic vessel development in neuropilin 2 mutant miceSemantic proximity Read ↗

TGFβ signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin.Semantic proximity Read ↗

Lymphatic Vasculature DevelopmentSemantic proximity Read ↗

Class 3 semaphorins in cardiovascular development.Semantic proximity Read ↗

The emerging role of class-3 semaphorins and their neuropilin receptors in oncologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.