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Article

RNA editing derived epitopes function as cancer antigens to elicit immune responses

19 Sept 2018

Abstract excerpt

Abstract In addition to genomic mutations, RNA editing is another major mechanism creating sequence variations in proteins by introducing nucleotide changes in mRNA sequences. Deregulated RNA editing contributes to different types of human diseases, including cancers. Here we report that peptides generated as a consequence of RNA editing are indeed naturally presented by human leukocyte antigen (HLA) molecules....

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PMID: 30254248
DOI: 10.1038/s41467-018-06405-9

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