Fibroblast-growth-factor receptor mutations in human skeletal disorders.

Abstract excerpt

Fibroblast-growth-factor receptors (FGFRs), members of the tyrosine-kinase receptor family, play a crucial role in signal transduction and development. Recently, unique mutations in three human FGFR-encoding genes (FGFR1-3) have been identified as the cause of a variety of skeletal disorders. Comparison of these specific mutations with the resulting phenotypes is now providing new insight into the role of these...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to Receptors, Fibroblast Growth Factor