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Article

The K-path entrance in cytochrome c oxidase is defined by mutation of E101 and controlled by an adjacent ligand binding domain.

Biochimica et biophysica acta. Bioenergetics - 1 Sept 2018

Hiser Carrie, Liu Jian, Ferguson-Miller Shelagh

Abstract excerpt

Three mutant forms of Rhodobacter sphaeroides cytochrome c oxidase (RsCcO) were created to test for multiple K-path entry sites (E101W), the existence of an "upper ligand site" (M350 W), and the nature and binding specificity of the "lower ligand site" (P315W/E101A) in the region of a crystallographically-defined deoxycholate at the K-path entrance. The effects of inhibitory and stimulatory detergents (dodecyl...

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Identifiers

PMID: 29626419
DOI: 10.1016/j.bbabio.2018.03.017
PMCID: PMC6078815

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