Article
Naso-maxillary deformity due to frontonasal expression of human transthyretin gene in transgenic mice.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2002
Noguchi Hiromitsu, Kaname Tadashi, Sekimoto Tomohisa, Senba Kei, Nagata Yasushi, Araki Masatake, Abe Makoto, Nakagata Naomi, Ono Tomomichi, Yamamura Ken-Ichi, Araki Kimi
Abstract excerpt
BACKGROUND: Retinoic acid, a metabolic product of retinol, is essential for craniofacial morphogenesis. Transthyretin (TTR) is a plasma protein delivering retinol to tissues. We produced several transgenic mouse lines using the human mutant TTR (hTTRMet30) gene to establish a mouse model of familial amyloidotic polyneuropathy. One of the lines showed an autosomal dominant inheritance of naso-maxillary deformity...
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