Article
Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.
BMC cell biology - 28 Oct 2002
Ramalho José S, Anders Ross, Jaissle Gesine B, Seeliger Mathias W, Huxley Clare, Seabra Miguel C
Abstract excerpt
BACKGROUND: Transgenic mice have proven to be a powerful system to study normal and pathological gene functions. Here we describe an attempt to generate a transgenic mouse model for choroideremia (CHM), a slow-onset X-linked retinal degeneration caused by mutations in the Rab Escort Protein-1 (REP1) gene. REP1 is part of the Rab geranylgeranylation machinery, a modification that is essential for Rab function in...
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