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Article

The pathogenesis of transthyretin tissue deposition: lessons from transgenic mice.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Aug 2003

Buxbaum Joel, Tagoe Clement, Gallo Gloria, Reixach Natalia, French David

Abstract excerpt

Attempts to produce animal models of the human transthyretin deposition disorders have not been as successful as investigators would wish. While random genomic insertion of mutant and wild-type human transthyretin genes has, in some instances, produced tissue deposits consisting of the human protein, in no case has a model faithfully reproduced the neuropathic pathology seen in FAP patients. Examining all the...

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Source

Identifiers

PMID: 14640034

Genes

FAP
TTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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