Article
Systemic amyloidosis in transgenic mice carrying the human mutant transthyretin (Met30) gene. Pathologic similarity to human familial amyloidotic polyneuropathy, type I.
The American journal of pathology - 1 Feb 1991
Yi S, Takahashi K, Naito M, Tashiro F, Wakasugi S, Maeda S, Shimada K, Yamamura K, Araki S
Abstract excerpt
To analyze the pathologic processes of amyloid deposition in type I familial amyloidotic polyneuropathy (FAP), mice were made transgenic by introducing the human mutant transthyretin (TTR) gene. In these transgenic mice, amyloid deposition started in the gastrointestinal tract, cardiovascular sys...
Topics
- Amyloid
- Amyloidosis
- Animals
- Genes
- Histocytochemistry
- Humans
- Immunohistochemistry
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Nervous System Diseases
- Prealbumin