Article
Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 2002
Hoshida Yoshihiko, Hongyo Tadashi, Nakatsuka Shin-ichi, Nishiu Mieko, Takakuwa Tetsuya, Tomita Yasuhiko, Nomura Taisei, Aozasa Katsuyuki
Abstract excerpt
Post-transplantation lymphoproliferative disorder (PT-LPD) is characterized by lymphoid proliferation after organ or bone marrow transplantation. In Western countries, most cases of PT-LPD are B-cell-derived and Epstein-Barr virus-associated, in which alterations of c-myc, p53, and N-ras genes might play a role in disease progression. In Japan, PT-LPD of T- and NK/T-cell types are not uncommon in renal transplant...
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