Canine leukocyte adhesion deficiency: presence of the Cys36Ser beta-2 integrin mutation in an affected US Irish Setter cross-breed dog and in US Irish Red and White Setters.

Abstract excerpt

Canine leukocyte adhesion deficiency (CLAD) is a primary immunodeficiency disease characterized by recurrent bacterial infections in the presence of marked leukocytosis. The disease was 1st described in the mid-1980s in a cross-breed Irish Setter Dog in the United States. It results from a defective beta-2 subunit of heterodimeric leukocyte adhesion proteins. The causative mutation for CLAD in Irish Setter Dogs...

Topics

• Animals
• Base Sequence
• Breeding
• CD18 Antigens
• Dog Diseases
• Dogs
• Female
• Leukocyte-Adhesion Deficiency Syndrome
• Male
• Mutation
• Pedigree
• United States