Article
Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1992
Shuster D E, Kehrli M E, Ackermann M R, Gilbert R O
Abstract excerpt
Two point mutations were identified within the gene encoding bovine CD18 in a Holstein calf afflicted with leukocyte adhesion deficiency (LAD). One mutation causes an aspartic acid to glycine substitution at amino acid 128 (D128G) in the highly conserved extracellular region of this adhesion glycoprotein, a region where several mutations have been found to cause human LAD. The other mutation is silent. Twenty...
Topics
- Alleles
- Animals
- Antigens, CD
- Base Sequence
- Blotting, Northern
- CD18 Antigens
- Cattle
- Cattle Diseases
- Female
- Genetic Carrier Screening
- Genotype