Article
Attenuation of catalase activity in the malignant phenotype plays a functional role in an in vitro model for tumor progression.
Cancer letters - 28 Nov 2001
Gupta A, Butts B, Kwei K A, Dvorakova K, Stratton S P, Briehl M M, Bowden G T
Abstract excerpt
We have developed an in vitro model to study the molecular mechanisms of tumor progression. Using repeated treatments with ionizing radiation or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), we caused malignant progression of a papilloma producing mouse keratinocyte cell line, 308 cells. In a previous study we have shown that the malignant variants of 308 cells have elevated reactive oxygen species (ROS) levels,...
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