Article
Inducible differentiation and morphogenesis of bipotential liver cell lines from wild-type mouse embryos.
Hepatology (Baltimore, Md.) - 1 Oct 2002
Strick-Marchand Hélène, Weiss Mary C
Abstract excerpt
This work shows that hepatic cell lines reproducibly can be derived from E14 embryos of many mouse inbred strains. These bipotential mouse embryonic liver (BMEL) cell lines present a mixed morphology, containing both epithelial and palmate-like cells, and an uncoupled phenotype, expressing hepatocyte transcription factors (HNF1alpha, HNF4alpha, GATA4) but not functions (apolipoproteins, albumin). BMEL cells are...
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