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Article

BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.

Nature biotechnology - 1 Nov 2006

Gouon-Evans Valerie, Boussemart Lise, Gadue Paul, Nierhoff Dirk, Koehler Christoph I, Kubo Atsushi, Shafritz David A, Keller Gordon

Abstract excerpt

When differentiated in the presence of activin A in serum-free conditions, mouse embryonic stem cells efficiently generate an endoderm progenitor population defined by the coexpression of either Brachyury, Foxa2 and c-Kit, or c-Kit and Cxcr4. Specification of these progenitors with bone morphogenetic protein-4 in combination with basic fibroblast growth factor and activin A results in the development of hepatic...

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PMID: 17086172
DOI: 10.1038/nbt1258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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