Article
The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death.
Cell death and differentiation - 1 Mar 2019
Vial Jonathan, Royet Amélie, Cassier Philippe, Tortereau Antonin, Dinvaut Sarah, Maillet Denis, Gratadou-Hupon Lise, Creveaux Marion, Sadier Alexa, Tondeur Garance, Léon Sophie, Depaepe Lauriane, Pantalacci Sophie, de la Fouchardière Arnaud, Micheau Olivier, Dalle Stéphane, Laudet Vincent, Mehlen Patrick, Castets Marie
Abstract excerpt
Ectodysplasin receptor EDAR is seen as a typical Tumor Necrosis Factor receptor (TNFR) family member known to interact with its ligand Eda-A1, and signaling mainly through the nuclear factor-kappaB (NF-κB) and c-jun N-terminal kinases pathways. Mutations in genes that encode proteins involved in EDAR transduction cascade cause anhidrotic ectodermal dysplasia. Here, we report an unexpected pro-apoptotic activity...
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