A mutant plasma membrane protein is stabilized upon loss of Yvh1, a novel ribosome assembly factor.

doi:10.1534/genetics.108.100099

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Article

A mutant plasma membrane protein is stabilized upon loss of Yvh1, a novel ribosome assembly factor.

Genetics - 1 Mar 2009

Liu Yu, Chang Amy

Abstract excerpt

Pma1-10 is a mutant plasma membrane ATPase defective at the restrictive temperature in stability at the cell surface. At 37 degrees, Pma1-10 is ubiquitinated and internalized from the plasma membrane for degradation in the vacuole. YVH1, encoding a tyrosine phosphatase, is a mutant suppressor of pma1-10; in the absence of Yvh1, Pma1-10 remains stable at the plasma membrane, thereby permitting cells to grow. The...

Topics

Dual-Specificity Phosphatases
Mutant Proteins
Mutation
Protein Stability
Protein Structure, Tertiary
Proton-Translocating ATPases
Ribosomal Proteins
Ribosome Subunits, Large, Eukaryotic
Ribosomes
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 19114459
DOI: 10.1534/genetics.108.100099
PMCID: PMC2651063

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