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Article

Binding of protein kinase B to the plakin family member periplakin.

Journal of cell science - 15 Oct 2002

van den Heuvel A Pieter J, de Vries-Smits Alida M M, van Weeren Pascale C, Dijkers Pascale F, de Bruyn Kim M T, Riedl Jürgen A, Burgering Boudewijn M T

Abstract excerpt

The serine/threonine kinase protein kinase B (PKB/c-Akt) acts downstream of the lipid kinase phosphoinositide 3-kinase (PI3K) and functions as an essential mediator in many growth-factor-induced cellular responses such as cell cycle regulation, cell survival and transcriptional regulation. PI3K activation generates 3'-phosphorylated phosphatidylinositol lipids (PtdIns3P) and PKB activation requires...

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Identifiers

PMID: 12244133
DOI: 10.1242/jcs.00069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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