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Article

A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092.

Journal of cell science - 15 Oct 2002

von Kobbe Cayetano, Bohr Vilhelm A

Abstract excerpt

Werner syndrome is a premature aging disorder caused by the lack of an active Werner syndrome protein (WRN). The patients suffer from many of the ailments seen at a much later stage in the life of normal individuals. WRN is a nuclear protein and contains a nuclear localization signal (NLS) in its C-terminal region. Inside the nucleus, WRN is mainly located in the nucleoli and in nuclear foci. To begin to...

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Source

Identifiers

PMID: 12244128
DOI: 10.1242/jcs.00076

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease.Semantic proximity Read ↗

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.Semantic proximity Read ↗

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