Development of Saccharomyces cerevisiae as a Model Pathogen: A System for the Genetic Identification of Gene Products Required for Survival in the Mammalian Host Environment

Abstract excerpt

Saccharomyces cerevisiae, a close relative of the pathogenic Candida species, is an emerging opportunistic pathogen. An isogenic series of S. cerevisiae strains, derived from a human clinical isolate, were used to examine the role of evolutionarily conserved pathways in fungal survival in a mouse host. As is the case for the corresponding Candida albicans and Cryptococcus neoformans mutants, S. cerevisiae purine...

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