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Article

Glycolytic inhibition by mutation of pyruvate kinase gene increases oxidative stress and causes apoptosis of a pyruvate kinase deficient cell line.

Experimental hematology - 1 Aug 2007

Aisaki Ken-ichi, Aizawa Shin, Fujii Hisaichi, Kanno Jun, Kanno Hitoshi

Abstract excerpt

OBJECTIVE: SLC3 is a Friend erythroleukemic cell line established from the Pk-1(slc) mouse, a mouse model of red blood cell type-pyruvate kinase (R-PK) deficiency. This study was aimed to elucidate the mechanisms attributing to apoptosis induced by R-PK deficiency. MATERIALS AND METHODS: SLC3 and a control Friend cell line, CBA2, were cultured in a condition of glucose deprivation or supplementation with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17662887
DOI: 10.1016/j.exphem.2007.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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