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Article

Progression of nigrostriatal dysfunction in a parkin kindred: an [18F]dopa PET and clinical study

20 Sept 2002

Abstract excerpt

Molecular and clinical characterization of parkin-associated parkinsonism is well described; however, there are no data available on progression of dopamine terminal dysfunction in parkin-associated disease. We have used [(18)F]dopa PET serially to study members of a family with young-onset parkinsonism who are compound heterozygous for mutations in the parkin gene, having an exonic deletion and a novel intronic...

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PMID: 12244082
DOI: 10.1093/brain/awf237

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