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Article

Mutation of ras oncogene in di-isopropanolnitrosamine-induced rat thyroid carcinogenesis.

Virchows Archiv : an international journal of pathology - 1 Sept 2002

Kobayashi Yoshihiko, Kawaoi Akira, Katoh Ryohei

Abstract excerpt

To clarify the role of ras gene mutation in thyroid tumorigenesis, DNAs extracted from various rat thyroid lesions induced by di-isopropanolnitrosamine (DIPN) administration were analyzed using the microdissection-polymerase chain reaction-direct sequence (MD-PCR-DS) method. The MD-PCR-DS method revealed that K- ras gene mutation (G-A transition at codon 12) was frequently detected in nodular lesions (incidence...

Topics

Animals
Carcinogens
Genes, ras
Male
Mutation
Nitrosamines
Rats
Rats, Wistar
Thyroid Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12242526
DOI: 10.1007/s00428-002-0608-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12242526-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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