Article
Phenotype of Per1- and Per2-expressing neurons in the suprachiasmatic nucleus of a diurnal rodent (Arvicanthis ansorgei): comparison with a nocturnal species, the rat.
Cell and tissue research - 1 Oct 2002
Dardente Hugues, Klosen Paul, Caldelas Ivette, Pévet Paul, Masson-Pévet Mireille
Abstract excerpt
In mammals, the suprachiasmatic nuclei (SCN) are the site of the master circadian pacemaker whose molecular core mechanism is based on interlocking transcriptional/translational feedback loops involving clock genes. Among clock genes, Per1 and Per2 are important for both the maintenance of circadian rhythmicity and entrainment to light cues. Several circadian rhythms (e.g., locomotor activity) present opposite...
Topics
- Animals
- Biological Clocks
- Cell Cycle Proteins
- Circadian Rhythm
- Darkness
- Gene Expression Regulation
- Light
- Male
- Neurons
- Nuclear Proteins
- Period Circadian Proteins
- Phenotype
- RNA, Messenger
- Rats