Article
Cellular distribution of the splice variants of the receptor for pituitary adenylate cyclase-activating polypeptide (PAC(1)-R) in the rat brain by in situ RT-PCR.
Brain research. Molecular brain research - 10 Jan 2000
Zhou C J, Kikuyama S, Shibanuma M, Hirabayashi T, Nakajo S, Arimura A, Shioda S
Abstract excerpt
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide and its specific receptor (the PAC(1) receptor) is widely distributed in the rat brain. It has been reported that alternative splicing of the region encoding the third intracellular loop of the PAC(1) receptor generates six isoforms which are differentially coupled to signal transduction pathways, but the precise distribution...
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