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Article

Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8+ T cells.

Blood - 1 Feb 2008

Guihot Amélie, Oksenhendler Eric, Galicier Lionel, Marcelin Anne-Geneviève, Papagno Laura, Bedin Anne-Sophie, Agbalika Félix, Dupin Nicolas, Cadranel Jacques, Autran Brigitte, Carcelain Guislaine

Abstract excerpt

Multicentric Castleman disease (MCD) is a devastating human herpesvirus 8 (HHV-8)-related lymphoproliferative disorder that occurs in immunocompromised persons. To determine the role of immune responses in MCD, we studied the frequency, antigenic repertoire, differentiation, and functional profile of HHV-8-specific CD8(+) T cells in MCD patients and in human immunodeficiency virus-coinfected asymptomatic HHV-8...

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Source

Identifiers

PMID: 18000163
DOI: 10.1182/blood-2007-03-080648

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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