Article
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters.
British journal of cancer - 9 Sept 2002
Fritz G, Brachetti C, Bahlmann F, Schmidt M, Kaina B
Abstract excerpt
In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for (32)P-ADP-ribosylation...
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