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Article

Conformation of ligands bound to the muscarinic acetylcholine receptor.

Molecular pharmacology - 1 Oct 2002

Furukawa Hiroyasu, Hamada Toshiyuki, Hayashi Mariko K, Haga Tatsuya, Muto Yutaka, Hirota Hiroshi, Yokoyama Shigeyuki, Nagasawa Kazuo, Ishiguro Masaji

Abstract excerpt

Many biogenic amines evoke a variety of physiological responses by acting on G protein-coupled receptors. We have determined the conformation of two acetylcholine analogs, (S)-methacholine and (2S,4R,5S)-muscarine, bound to the M(2) muscarinic acetylcholine receptor (M(2) mAChR) by NMR spectroscopy. The analysis of the transferred nuclear Overhauser effect indicated that the receptor selectively recognized the...

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Identifiers

PMID: 12237324
DOI: 10.1124/mol.62.4.778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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