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Huntington's Disease: A Clinical Review

27 Aug 2022

Abstract excerpt

The Huntington's gene on chromosome 4 has a dominantly inherited CAG trinucleotide repeat expansion, ultimately resulting in Huntington's disease (HD), a completely penetrant neurological condition. The frequency is 10-100 times higher in the population descended from Europe than in East Asia. Through various processes, including impairment of proteostasis, transcription, and cell function, as well as direct...

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PMID: 36176885
DOI: 10.7759/cureus.28484

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