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Article

Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 1999

Hans M, Luvisetto S, Williams M E, Spagnolo M, Urrutia A, Tottene A, Brust P F, Johnson E C, Harpold M M, Stauderman K A, Pietrobon D

Abstract excerpt

Mutations in alpha1A, the pore-forming subunit of P/Q-type calcium channels, are linked to several human diseases, including familial hemiplegic migraine (FHM). We introduced the four missense mutations linked to FHM into human alpha1A-2 subunits and investigated their functional consequences aft...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10024348
PMCID: PMC6782159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10024348-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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