Article
Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America.
The Journal of infectious diseases - 1 Oct 2002
Cortese Joseph F, Caraballo Alejandro, Contreras Carmen E, Plowe Christopher V
Abstract excerpt
Multidrug resistance is a major obstacle to the control of Plasmodium falciparum malaria, and its origins and modes of dissemination are imperfectly understood. In this study, haplotyping and microsatellite analysis of malaria from 5 regions of the South American Amazon support the conclusion that the parasite mutations conferring mid- and high-level resistance to the antifolate combination...
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