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Article

Polyploid giant cancer cells induced by Docetaxel exhibit a senescence phenotype with the expression of stem cell markers in ovarian cancer cells.

PloS one - 1 Jan 2024

Zhao Song, Wang Lili, Ouyang Mingyue, Xing Sining, Liu Shuo, Sun Lingyan, Yu Huiying

Abstract excerpt

Docetaxel (Doc) plays a crucial role in clinical antineoplastic practice. However, it is continuously documented that tumors frequently develop chemoresistance and relapse, which may be related to polyploid giant cancer cells (PGCCs). The aim of this study was investigate the formation mechanism and biological behavior of PGCCs induced by Doc. Ovarian cancer cells were treated with Doc, and then the effect of Doc...

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Identifiers

PMID: 38990953
DOI: 10.1371/journal.pone.0306969
PMCID: PMC11239069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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