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Article

Experimental control of pancreatic development and maintenance.

Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 2002

Holland Andrew M, Hale Michael A, Kagami Hideaki, Hammer Robert E, MacDonald Raymond J

Abstract excerpt

To investigate the role of the HOX-like homeoprotein PDX1 in the formation and maintenance of the pancreas, we have genetically engineered mice so that the only source of PDX1 is a transgene that can be controlled by the application of tetracycline or its analogue doxycycline. In these mice the coding region for the tetracycline-regulated transactivator (tTA(off)) has replaced the coding region of the endogenous...

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Identifiers

PMID: 12221286
DOI: 10.1073/pnas.192255099
PMCID: PMC129428

Genes

PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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