Article
Pancreatic Mesenchyme Regulates Epithelial Organogenesis throughout Development
6 Sept 2011
Abstract excerpt
The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the mature organ. During organogenesis, the epithelial cells receive essential signals from the overlying mesenchyme. Previous studies, focusing on ex vivo tissue explants or complete knockout mice, have identified an important role for the mesenchyme in regulating the expansion of progenitor cells in the early pancreas...
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