Article
The absence of evidence for major effects of the frequent SNP +299G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes.
Diabetes research and clinical practice - 1 Sept 2003
Ochi Masaaki, Osawa Haruhiko, Onuma Hiroshi, Murakami Akiko, Nishimiya Tatsuya, Shimada Fumio, Kato Kenichi, Shimizu Ikki, Shishino Koji, Murase Mitsuharu, Fujii Yasuhisa, Ohashi Jun, Makino Hideichi
Abstract excerpt
Resistin, specifically secreted from adipocytes, antagonizes insulin and represents a promising candidate gene for type 2 diabetes. We reported that a frequent single nucleotide polymorphism (SNP) +299G>A in this gene is not associated with type 2 diabetes. To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity,...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- Adult
- Aged
- Cyclic Nucleotide Phosphodiesterases, Type 3
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Female
- Gene Frequency
- Genetic Predisposition to Disease