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Article

Sperm abnormalities in heterozygous acid sphingomyelinase knockout mice reveal a novel approach for the prevention of genetic diseases.

The American journal of pathology - 1 Jun 2007

Butler Avigdor, Gordon Ronald E, Gatt Shimon, Schuchman Edward H

Abstract excerpt

Acid sphingomyelinase knockout mice are a model of the inherited human disorder types A and B Niemann-Pick disease. Herein, we show that heterozygous (ASMKO(+/-)) mice have two distinct sperm populations resembling those found in normal and mutant animals, respectively, and that these two populat...

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Identifiers

PMID: 17525274
DOI: 10.2353/ajpath.2007.061002
PMCID: PMC1899442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17525274-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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