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Article

Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.

Neuropharmacology - 1 Jul 2002

Wong John Y F, Ross Shelley A, McColl Craig, Massalas Jim S, Powney Emma, Finkelstein David I, Clark Malcolm, Horne Malcolm K, Berkovic Samuel F, Drago John

Abstract excerpt

The genetic basis of a number of epilepsy syndromes has been identified but the precise mechanism whereby these mutations produce seizures is unknown. Three mutations of the alpha(4) subunit of the neuronal nicotinic acetylcholine receptor (nAChR) have been identified in autosomal dominant nocturnal frontal lobe epilepsy. In vitro studies of two mutations suggest an alteration of receptor function resulting in...

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PMID: 12213259
DOI: 10.1016/s0028-3908(02)00067-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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