Mutated nicotinic receptors responsible for autosomal dominant nocturnal frontal lobe epilepsy are more sensitive to carbamazepine.

doi:10.1111/j.1528-1157.1999.tb00848.x

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Article

Mutated nicotinic receptors responsible for autosomal dominant nocturnal frontal lobe epilepsy are more sensitive to carbamazepine.

Epilepsia - 1 Sept 1999

Picard F, Bertrand S, Steinlein O K, Bertrand D

Abstract excerpt

PURPOSE: The recent linkage between a genetically transmissible form of epilepsy (ADNFLE) and mutations within the alpha4 subunit, one component of the major brain neuronal nicotinic acetylcholine receptor (nAChR), raises the question of the role of this receptor in epileptogenesis. Although acting by different mechanisms, the two genetic alterations so far identified both render the nAChR less efficient. In view...

Topics

Animals
Anticonvulsants
Carbamazepine
Dose-Response Relationship, Drug
Epilepsy, Frontal Lobe
Evoked Potentials
Humans
Mutation
Oocytes
Patch-Clamp Techniques
Polymorphism, Genetic
Receptors, Nicotinic
Valproic Acid
Xenopus

Source

Open in PubMed

Identifiers

PMID: 10487182
DOI: 10.1111/j.1528-1157.1999.tb00848.x

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