Article
Rapid prenatal confirmation of LIT1 hypomethylation using a novel quantitative method (E-Q-PCR) in fetuses with Beckwith-Wiedemann syndrome impressed with ultrasonography.
Fertility and sterility - 1 Oct 2008
Ma Gwo-Chin, Chang Shuenn-Dyh, Chang Yu, Chang Shun-Ping, Yang Chin-Wen, Lee Ming-Jen, Lee Tsung-Hsien, Chen Ming
Abstract excerpt
We described a simplified and high-performance test (E-Q-PCR) for rapid assessment of the DNA methylation status at LIT1, a major genetic locus of Beckwith-Wiedemann syndrome (BWS). The E-Q-PCR test can detect and quantify the methylation changes between BWS fetuses and unaffected individuals in aminocytes as well as in lymphocytes and can be completed in 1 working day, and thus is a useful method for prenatal...
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